| Title |
A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period
|
|---|---|
| Published in |
Molecular Cell, October 2015
|
| DOI | 10.1016/j.molcel.2015.08.022 |
| Pubmed ID | |
| Authors |
Min Zhou, Jae Kyoung Kim, Gracie Wee Ling Eng, Daniel B. Forger, David M. Virshup |
| Abstract |
Period (PER) protein phosphorylation is a critical regulator of circadian period, yet an integrated understanding of the role and interaction between phosphorylation sites that can both increase and decrease PER2 stability remains elusive. Here, we propose a phosphoswitch model, where two competing phosphorylation sites determine whether PER2 has a fast or slow degradation rate. This mathematical model accurately reproduces the three-stage degradation kinetics of endogenous PER2. We predict and demonstrate that the phosphoswitch is intrinsically temperature sensitive, slowing down PER2 degradation as a result of faster reactions at higher temperatures. The phosphoswitch provides a biochemical mechanism for circadian temperature compensation of circadian period. This phosphoswitch additionally explains the phenotype of Familial Advanced Sleep Phase (FASP) and CK1ε(tau) genetic circadian rhythm disorders, metabolic control of PER2 stability, and how drugs that inhibit CK1 alter period. The phosphoswitch provides a general mechanism to integrate diverse stimuli to regulate circadian period. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 2 | 25% |
| United States | 2 | 25% |
| Germany | 1 | 13% |
| United Kingdom | 1 | 13% |
| Unknown | 2 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 50% |
| Scientists | 4 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 162 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Sweden | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 158 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 30 | 19% |
| Student > Master | 23 | 14% |
| Researcher | 22 | 14% |
| Student > Bachelor | 19 | 12% |
| Professor | 12 | 7% |
| Other | 21 | 13% |
| Unknown | 35 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 51 | 31% |
| Agricultural and Biological Sciences | 24 | 15% |
| Neuroscience | 14 | 9% |
| Mathematics | 9 | 6% |
| Medicine and Dentistry | 8 | 5% |
| Other | 15 | 9% |
| Unknown | 41 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 93. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 February 2024.
All research outputs
#455,568
of 25,373,627 outputs
Outputs from Molecular Cell
#266
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Outputs of similar age
#6,296
of 286,876 outputs
Outputs of similar age from Molecular Cell
#6
of 95 outputs
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We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.