Systematic modeling-driven experiments identify distinct molecular clockworks underlying hierarchically organized pacemaker neuron... https://t.co/aKcaft6YJI
Systematic modeling-driven experiments identify distinct molecular clockworks underlying hierarchically organized pacemaker neurons | Proceedings of the National Academy of Sciences https://t.co/DbZNE21Xm7
RT @interactivefly: Jeong, E. M., Kwon, M., Cho, E., Lee, S. H., Kim, H., Kim, E. Y. and Kim, J. K. (2022). Systematic modeling-driven expe…
Jeong, E. M., Kwon, M., Cho, E., Lee, S. H., Kim, H., Kim, E. Y. and Kim, J. K. (2022). Systematic modeling-driven experiments identify distinct molecular clockworks underlying hierarchically organized pacemaker neurons. Proc Natl Acad Sci U S A 119(8). ht
Fly clock neurons ARE clock neurons because they express the core clock transcription-translation feedback loop. But does the molecular clock run the same in all clock neuron groups? Data suggest that PER and CLK regulation differ between sLNvs and DN1s.
We used the combination of #modeling and experiments to identify different molecular mechanisms between master and slave clocks. This solves the mystery about the paradoxical characteristics of #circadian rhythms (robustness and plasticity). https://t.co/i